COMPOUNDS BASED ON TRIAZOLOPYRIMIDINE AND THEIR SALTS, COMPOSITIONS BASED ON THEM AND WAYS OF THEIR USE Russian patent published in 2023 - IPC C07D487/04 C07D519/00 A61K31/519 A61P35/00 

FIELD: organic chemistry.

SUBSTANCE: group of inventions includes a compound of formula (IV), its salt, a pharmaceutical composition containing it, and its use. In formula (IV), R₇ is selected from C₁-C₆alkyl, optionally substituted with a 5-membered heteroaryl selected from furyl or thienyl, or a six- to 10-membered aryl, which is optionally substituted with halogen; C₃-C₈cycloalkyl, which can be fused with phenyl and is optionally substituted with hydroxyl, C₁-C₆alkoxy, phenyl optionally substituted with 1–2 halogen atoms, or where R₁₅ represents C₁-C₆alkyl; A C₃-C₈ unsaturated hydrocarbon ring substituted with a -COOR₁₇ group, where R₁₇ represents a C₁-C₆alkyl; groups where R₁₄ is selected from the group consisting of H, C₁-C₆alkyl and -Boc; 5-membered heterocyclyl containing 1–2 nitrogen atoms condensed with phenyl; 5-membered heteroaryl containing 2 nitrogen atoms fused with phenyl; and groups.

(IV)

EFFECT: compound of formula (IV) with inhibitory activity against NAE.

8 cl, 2 tbl, 2 ex