NANOSTRUCTURED COMPOSITIONS FOR DELIVERY OF SILIBININ AND OTHER ACTIVE INGREDIENTS FOR TREATING EYE DISEASES Russian patent published in 2020 - IPC A61K31/357 A61K9/51 A61P27/02 

Abstract RU 2726193 C2

FIELD: pharmaceutical industry.

SUBSTANCE: invention relates to a composition for topical treatment of neurodegenerative eye diseases selected from age-related macular degeneration (AMD), neovascular glaucoma, diabetic retinopathy (DR) and uveitis. Composition for topical treatment of neurodegenerative eye diseases selected from age-related macular degeneration (AMD), neovascular glaucoma, diabetic retinopathy (DR) and uveitis, containing as an active ingredient silibinin, or sorafenib, or curcumin, or latanoprost, in which: silibinin, or sorafenib, or curcumin, or latanoprost is included in calixarene-based nanostructured systems, or silibinin or sorafenib is included in micellar and nanoparticle systems based on amphiphilic inulin copolymers.

EFFECT: composition described above is effective for topical treatment of neurodegenerative eye diseases selected from age-related macular degeneration (AMD), neovascular glaucoma, diabetic retinopathy (DR) and uveitis, improves transportation and delivery of the active ingredient into structures arranged in a posterior segment of eyes, such as a vitreous body or retina.

5 cl, 19 dwg, 12 tbl, 4 ex

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RU 2 726 193 C2

Authors

Consoli, Grazia Maria Letizia

Cavallaro, Gennara

Bondi', Maria Luisa

Blanco, Anna Rita

Viola, Santa

Esposito, Emanuela

Cuzzocrea, Salvatore

Guarneri, Patrizia

Papasergi, Salvatore

Deidda, Irene

La Marca, Clara

Saladino, Patrizia

Granata, Giuseppe

Pitarresi, Giovanna

Licciardi, Mariano

Giammona, Gaetano

Craparo, Emanuela Fabiola

Dates

2020-07-09Published

2015-10-09Filed