FIELD: chemistry.
SUBSTANCE: invention relates to N,N'-bis(3-aminopropyl)butane-1,4-diamino derivatives of fusidic acid of formula (1) and (2): (2Z)-2-((3β,4α,8α,11α,14β,16β)-16-(acetyloxy)-3-{[3-({4-[(3-aminopropyl)amino]butyl}amino)propyl]amino}-11-hydroxy-4,8,10,14-tetramethylgonane-17-ylidene)-6-methylhept-5-enoic acid (1) and methyl (2Z)-2-((3β,4α,8α,11α,14β,16β)-16-(acetyloxy)-3-{[3-({4-[(3-aminopropyl)amino]butyl}amino)propyl]amino}-11-hydroxy-4,8,10,14-tetramethylgonane-17-ylidene)-6-methylhept-5-enoate (2). Invention also relates to use of N,N'-bis(3-aminopropyl)butane-1,4-diamino derivatives of fusidic acid.
EFFECT: obtaining novel compounds exhibiting antimicrobial activity against strains of gram-positive bacteria Staphylococcus aureus and pathogenic fungal cultures Cryptococcus neoformans.
2 cl, 2 tbl, 2 ex
| Title |
Year |
Author |
Number |
| (2Z)-2-[(3Β, 4Α, 8Α, 11Α, 14Β, 16Β)-16-(ACETYLOXY)-3-({3-[(4-AMINOBUTYL)AMINO]PROPYL}AMINO)-11-HYDROXY-4,8,10,14-TETRAMETHYL GONANE-17-YLIDENE]-6-METHYLHEPT-5-ENOIC ACID WITH ANTIMICROBIAL AND FUNGICIDAL ACTIVITY AND METHOD FOR PRODUCTION THEREOF |
2019 |
- Salimova Elena Viktorovna
- Tretyakova Elena Valerevna
- Parfenova Lyudmila Vyacheslavovna
|
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|
RU2735665C1 |
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2021 |
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|
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