FIELD: medicine; pharmaceuticals.
SUBSTANCE: invention relates to derivatives of general formula (II)
,
where Y and Z are -O- and A is
,
where R1, R2, R3 independently represent OCH3; X is O; n equals 3 and m equals 1.
EFFECT: obtaining novel derivatives with bortezomib via boronic diester bonds, which are stable in a neutral medium, but which are capable of splitting in a slightly acidic medium (pH = 4_5–5_0), selecting a bortezomib for drug delivery, which can be used for transfer and extraction of bortezomib.
9 cl, 5 tbl, 14 dwg
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