BIODEGRADABLE NANO-CARRIER(S) (BPMOs) FOR NEUTRON CAPTURE THERAPY AND ITS METHODS Russian patent published in 2022 - IPC A61K41/00 A61K9/51 A61N5/10 A61K47/54 A61P35/00 

FIELD: nanotechnology; cancer therapy.

SUBSTANCE: composition for the treatment of carcinomas in a human, using boron-neutron capture therapy, is claimed, which includes a neutron capture agent and nanomaterial of biodegradable periodic mesoporous organosilica (hereinafter – BPMO) compounds. BPMO is modified by introduction of a disulfide bond, a tetrasulfide bond, or a protease-sensitive bond, and the surface of BPMO is modified using phosphonate. The invention also relates to a method for introduction of the neutron capture agent into nanomaterial of BPMO, which includes synthesis of BPMO, using a method for sol-gel synthesis, modification of the surface of BPMO, and loading of BPMO with the modified surface with the neutron capture agent. A method for neutron capture therapy in the treatment of cancer, using a composition, as well as kits for use in therapeutic purposes for the treatment of carcinomas are also claimed.

EFFECT: group of inventions provides new and improved methods for the treatment of cancer and immunological disorders.

18 cl, 6 dwg, 7 ex