FIELD: pharmaceuticals.
SUBSTANCE: invention relates to a spiro compound of general formula (III) and its pharmaceutically acceptable salts, which have inhibitory activity against ERK kinase. In this formula,
n is either 0 or 1; m is either 1 or 2; ring A means 
T1 means N, T2 and T3 each means CH; E1 means O; R1 is selected from H or C1-3-alkyl; R2 and R3 are each independently selected from H and C1-3-alkyl; R4 means H; R5, R7, R8 and R9 are each independently selected from H and C1-3-alkyl; R6 is selected from F, Cl, Br, I. The invention also relates to the use of a compound of general formula (III) in the preparation of a medicinal product for the treatment of diseases associated with ERK, a medicinal product having ERK kinase inhibitory activity.
EFFECT: using spiro compounds as ERK inhibitors.
18 cl, 2 dwg, 6 tbl, 11 ex
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