METHOD FOR PREDICTION OF SEVERE POST-EMBOLIZATION SYNDROME IN PATIENT WITH UTERINE MYOMA IN EARLY POSTOPERATIVE PERIOD Russian patent published in 2020 - IPC G01N33/52 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to obstetrics and gynecology, and can be used in predicting severe course post-embolization syndrome (PES) in women in early postoperative period after uterine myoma embolization. A method for prediction of severe clinical course of post-embolization syndrome in patients with hysteromyoma in the early postoperative period, characterized by the fact that such prognostic parameters as skin microcirculation indices – endothelial (E) and respiratory (R) oscillations of microcirculation are determined by laser Doppler flowmetry in conducting an occlusion test in females with hysteromyoma and additionally determining body weight index (BWI), in the period preceding surgical treatment by uterine artery embolization, wherein endothelial oscillations (E) and respiratory oscillations (R) are measured in perfusion units (pf units), and the index body weight = weight/height is measured in kg/m², wherein each risk factor after its measurement and wavelet transformation (E, R) or calculation of body weight index is multiplied by a regression coefficient (b), value of which for endothelial oscillations (E) is (-2.50); for respiratory oscillations (R) is 12.69; for body weight index is (-0.21); obtained digital values are summed up with adding to the obtained sum constant (6.67), thus at the first stage the value of intermediate value "z" is obtained by formula: z=[(-2.50⋅E)+(12.69⋅R)+(-0.21⋅BWI)]+6.67, where 6.67 is a constant; at the second stage, calculating a probability of developing a severe post-embolization syndrome by a logistic regression formula p=e^z(1+e^z), where p is a prognostic coefficient, wherein the value of the prognostic coefficient is greater than or equal to 0.25, the probability of developing a severe postembolization syndrome is high, and if the prognostic coefficient is less than 0.25, uterine myoma is referred to the low-risk group of severe postembolization syndrome.

EFFECT: method enables detecting groups of high risk of developing severe post-embolization syndrome in early postoperative period, increase reliability, information value, provide timely diagnosis of risk factors of severe post-embolization syndrome and complications after UAE, as well as ensure timely appointment of optimal treatment and management of patients in early postoperative period aimed at preventing and reducing the risk of developing complications following uterine artery embolization.

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