FIELD: biotechnology.
SUBSTANCE: described are variants of the Fc region, having high activity and/or selectivity of binding with FcγRIIb, compared to FcγRIIa (R-type), compared to polypeptide binding activity and/or selectivity, containing Fc-region, in which amino acid modification(s) was(were) not introduced; polypeptide comprising said version of Fc region. Also presented is a corresponding pharmaceutical composition for treating or preventing inflammatory diseases or oncological diseases.
EFFECT: versions of the FcγRIIb-specific Fc region are disclosed.
15 cl, 37 dwg, 27 tbl, 9 ex
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