FIELD: biotechnology.
SUBSTANCE: option of Fc-region of human IgG is proposed, FcγRIIb-binding activity which is maintained, and binding activities of this option with activating FcγR (FcγRIa, FcγRIIaR, FcγRIIaH and FcγRIIIaV) are reduced in comparison with the activity of Fc-region of native IgG. An antibody including the specified option of Fc region, a method for producing and application of this antibody to stimulate the removal of an antigen from plasma are also proposed.
EFFECT: invention makes it possible to reduce side effects, when using the antibody, induced by activating FcγR, while maintaining the capability of the antibody to eliminate antigens and while maintaining the capability to bind to FcγRIIb.
15 cl, 19 dwg, 23 tbl, 16 ex
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