FIELD: biotechnology; medicine.
SUBSTANCE: invention relates to biotechnology and medicine. Antineoplastic agent based on recombinant vaccinia virus strain contains recombinant strain VV-GMCSF-Lact of vaccinia virus in amount of (1-2)×107 PFU capable to suppress the growth of solid malignant tumour, deposited in the Federal Budget Institution of Science the State Scientific Centre of Virology and Biotechnology VECTOR under number V-688, and pharmaceutically acceptable solvent to 1 ml. Initial components are specified at content per 1 ml. Method for preparing the anti-tumour agent is also provided.
EFFECT: invention provides higher anti-tumour efficacy of the agent and wider range of its functional activity in relation to glioblastoma, lymphosarcoma and breast carcinoma (solid tumours of humans and animals).
7 cl, 3 dwg, 5 ex
| Title | Year | Author | Number |
|---|---|---|---|
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|
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|
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|
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|
RU2565544C2 |
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|
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|
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| RECOMBINANT ONCOLYTIC STRAIN OF L-IVP_ONCOQ VACCINIA VIRUS, CONTAINING GENES ENCODING GRANULOCYTE MACROPHAGE COLONY-STIMULATING FACTOR AND POLYEPITOPE IMMUNOGEN CONSISTING OF ANTIGEN EPITOPES, OVEREXPRESSING TUMOR CELLS IN OVARIAN CANCER | 2017 |
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| RECOMBINANT ONCOLYTIC STRAIN OF L-IVP_ONCOM VACCINIA VIRUS, CONTAINING GENES, ENCODING GRANULOCYTE MACROPHAGE COLONY-STIMULATING FACTOR AND POLYEPITOPE IMMUNOGEN CONSISTING OF ANTIGEN EPITOPES, OVEREXPRESSING TUMOR CELLS IN MELANOMA | 2017 |
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| M2-DEFECTIVE POXVIRUS | 2019 |
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