FIELD: biotechnology.
SUBSTANCE: invention concerns a recombinant oncolytic vaccinia virus L-IVP_oncoM deposited in the state collection of pathogens of viral infections and rickettsioses of Rospotrebnadzor State Research Center of Virology and Biotechnology ‘Vector’ under the number V-797. Proposed strain contains: A34R gene with two nucleotide substitutions; in the region of the viral thymidine kinase gene, the gene encoding granulocyte macrophage colony-stimulating factor; in the area of viral gene encoding viral growth factor, gene encoding polyepitopic immunogen. Polyepitope immunogen consists of epitopes of antigens NY-ESO-1, MART-1 (Melan-A), MAGE-A1, MAGE-A3, MAGE-C1, gp100, tyrosinase, TRP-2, TRAG-3.
EFFECT: presented strain can be used for the preparation of medicines used in the treatment of melanoma.
1 cl, 5 dwg, 11 ex
| Title | Year | Author | Number |
|---|---|---|---|
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|
RU2678056C1 |
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|
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|
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RU2621868C1 |
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RU2692628C1 |
