RECOMBINANT ONCOLYTIC STRAIN OF L-IVP_ONCOM VACCINIA VIRUS, CONTAINING GENES, ENCODING GRANULOCYTE MACROPHAGE COLONY-STIMULATING FACTOR AND POLYEPITOPE IMMUNOGEN CONSISTING OF ANTIGEN EPITOPES, OVEREXPRESSING TUMOR CELLS IN MELANOMA Russian patent published in 2019 - IPC C12N7/00 C12N7/01 C12N15/12 C12N15/27 

Abstract RU 2678060 C1

FIELD: biotechnology.

SUBSTANCE: invention concerns a recombinant oncolytic vaccinia virus L-IVP_oncoM deposited in the state collection of pathogens of viral infections and rickettsioses of Rospotrebnadzor State Research Center of Virology and Biotechnology ‘Vector’ under the number V-797. Proposed strain contains: A34R gene with two nucleotide substitutions; in the region of the viral thymidine kinase gene, the gene encoding granulocyte macrophage colony-stimulating factor; in the area of viral gene encoding viral growth factor, gene encoding polyepitopic immunogen. Polyepitope immunogen consists of epitopes of antigens NY-ESO-1, MART-1 (Melan-A), MAGE-A1, MAGE-A3, MAGE-C1, gp100, tyrosinase, TRP-2, TRAG-3.

EFFECT: presented strain can be used for the preparation of medicines used in the treatment of melanoma.

1 cl, 5 dwg, 11 ex

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RU 2 678 060 C1

Authors

Bauer Tatyana Valerevna

Kolosova Irina Valerevna

Tregubchak Tatyana Vladimirovna

Maksyutov Amir Zakievich

Gavrilova Elena Vasilevna

Maksyutov Rinat Amirovich

Dates

2019-01-22Published

2017-12-11Filed