ENANTIOMER OF SUBSTITUTED PHENYLPROPIONIC ACID AND A METHOD FOR PRODUCTION THEREOF, COMPOSITION THEREOF AND USE THEREOF Russian patent published in 2020 - IPC C07D209/82 A61K31/403 A61P3/04 A61P3/06 A61P3/10 

Abstract RU 2735524 C2

FIELD: pharmaceuticals.

SUBSTANCE: invention discloses an enantiomeric compound, which is (-)-2-[(2-(4-fluorobenzoyl)phenyl)amine]-3-[(4-(2-carbazole-ethoxy)phenyl)]propionic acid of formula (I) or its pharmaceutical salt, and method obtaining the compound and use thereof.

EFFECT: enantiomeric compound demonstrates relatively better activation of expression RXR/PPAR-, RXR/PPAR- and RXR/PPAR-heterodimers and low sugar content in the db/db mouse model compared to the (+)-enantiomer.

11 cl, 3 dwg, 4 tbl, 8 ex

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RU 2 735 524 C2

Authors

Yu, Jindi

Pan, Desi

Shan, Song

Li, Zhibin

Lu, Xianping

Dates

2020-11-03Published

2017-09-27Filed