METHOD N2 FOR PREPARING A SORBENT BASED ON COVALENTLY IMMOBILIZED AND CHEMICALLY MODIFIED LYSOZYME FOR SORPTION OF BACTERIAL ENDOTOXINS AND THE SORBENT ITSELF Russian patent published in 2020 - IPC C12N9/36 C12N11/02 

Abstract RU 2736150 C1

FIELD: medicine.

SUBSTANCE: invention relates to production of sorbents used for medical purposes, namely for extracorporeal therapy of the patients with sepsis with the use of biological liquids sorption. Obtained sorbent is characterized by improved properties of covalently immobilized lysozyme with various degrees of chemical modification of anisic aldehyde and depending on this by different degree of bacteriolytic activity and sorption characteristics.

EFFECT: technical result of invention is the creation of a more efficient hemocompatible sorbent with improved properties with the help of additional preliminary chemical modification of lysozyme with anisic aldehyde before immobilization of lysozyme and method for its creation.

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RU 2 736 150 C1

Authors

Levashov Pavel Andreevich

Adamova Irina Yurevna

Nelyub Vladimir Aleksandrovich

Matolygina Darya Andreevna

Dmitrieva Oksana Aleksandrovna

Ovchinnikova Ekaterina Dmitrievna

Eremeev Nikolaj Leonidovich

Levashov Andrej Vadimovich

Karelina Nataliya Vasilevna

Dates

2020-11-12Published

2019-10-29Filed