METHOD FOR PREDICTION OF THE RISK OF DEVELOPING ATHEROSCLEROTIC INVOLVEMENT OF CAROTID ARTERIES IN PATIENTS SUFFERING SYSTEMIC LUPUS ERYTHEMATOSUS Russian patent published in 2020 - IPC A61B5/00 

FIELD: medicine.

SUBSTANCE: invention refers to clinical medicine, particularly to rheumatology, cardiology, therapy. A set of diagnostic parameters is determined: age of first system lupus erythematosus (SLE) (x1) symptoms appearance, SLE duration at examination (x2), duration of nephritis (x3), heredity of cardiovascular diseases (x4), presence of smoking (x5), presence of arterial hypertension (x6), level of cholesterol (x7), value of atherogenicity index (x8). Based on the obtained data, each indicator is assigned a certain score and an integral index of a prediction of the risk of developing atherosclerotic involvement of carotid arteries with underlying SLE (P) is calculated by formula: P=6.598×x1+1.179×x2+0.855×x3+1.985× x4+0.066×x5+0.910×x6+1.058×x7+0.243×x8. Where: x1 is assigned "0 points", if the age of the first symptoms of SLE is less than 40 years, "1 point" - if 40 years and more; x2 is assigned "0 points" if the SLE duration is less than 12 months, "1 point" - if 12 months and more; x3 is assigned "0 points", if the nephritis duration is less than 24 months or there is no nephritis, "1 point" - if 24 months and more; x4 is assigned "0 points" if heredity in cardiovascular diseases is not burdened, "1 point" - heredity burdened; x5 is assigned "0 points" if the patient does not smoke, "1 point" - if smoked; x6 is assigned with "0 points", if there is no arterial hypertension, "1 point" - in the presence of arterial hypertension; x7 is assigned with "0 points", if cholesterol level is less than 5 mmol/l, "1 point" - if 5 mmol/l and more. If P is "4.5 or less", a low risk of developing atherosclerotic plaques is predicted in the patients with SLE. If P "from 4.6 to 5.5", a moderate risk is predicted; if P "from 5.6 to 7.0", a high risk is predicted; if P "from 7.1 and higher", a very high risk is predicted.

EFFECT: method enables more accurate prediction of the risk of developing atherosclerotic plaques in patients with SLE, provided fewer diagnostic indicators are determined, which is achieved by taking into account a diagnostically significant set of diagnostic indicators.

1 cl, 4 ex