N-LIPOIC AMINO ACID OR PEPTIDE, DERIVATIVES AND USE THEREOF Russian patent published in 2020 - IPC C07D339/04 A61K31/385 A61K38/00 A61K38/05 A61K38/06 A61P17/00 C07K5/06 C07K5/08 

FIELD: pharmaceuticals.

SUBSTANCE: invention refers to a method of treating a dermatological disorder specified in a group consisting of fine lines, wrinkles and age spots. Method comprises topical administration to a patient of a composition comprising a therapeutically effective amount of a compound comprising an N-lipoic amino acid or peptide derivative, having following formula (I): N-lipoic acid-(X)_n-ZR₁ Formula (I). Lipoic is a lipoic (Lp) radical, (X)_n is a peptide having n amino acid residues, wherein each of amino acid residues X is independently selected from any amino acid, n is an integer relating to range of 0–2, Z is a carboxy-terminal amino acid residue, wherein each of the amino acid residues is independently selected from any amino acid, R₁ denotes NHR₃, R₃ denotes H. Invention also discloses use of a therapeutic composition containing a compound of formula (I) and use of the compound of formula (I).

EFFECT: technical result of the disclosed method consists in using stable lipoic acid derivatives for treating a dermatologic disorder.

7 cl, 8 dwg, 9 ex