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2 642 882

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IPC

C07D403/04(2006-01-01)

A61K31/395(2006-01-01)

A61P31/04(2006-01-01)

(21) (22)

Application

2017102867, 2017-01-27

(24)

Start date

2017-01-27

(22)

Actual filing date

2017-01-27

(45)

Published

2018-01-30

(72)

Inventor

Ishmetova Rashida IrshotovnaIgnatenko Nina KonstantinovnaBelyaninova Irina AleksandrovnaGerasimova Natalya AvenirovnaEvstigneeva Natalya PetrovnaZilberberg Natalya VladimirovnaKungurov Nikolaj VasilevichRusinov Gennadij LeonidovichCharushin Valerij NikolaevichChupakhin Oleg Nikolaevich

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Uchrezhdenie Nauki Institut Organicheskogo Sinteza Im. I.Ya. Postovskogo Uralskogo Otdeleniya Rossijskoj Akademii Nauk Uro Ran)Gosudarstvennoe Byudzhetnoe Uchrezhdenie Sverdlovskoj Oblasti Nauchno-Issledovatelskij Institut Dermatovenerologii I Immunopatologii"

SELECTIVE ANTIBACTERIAL AGENTS, REPRESENTED BY 3-(AZOL-1-YL)-6-AMINO-SUBSTITUTED 1,2,4,5-TETRAZINES Russian patent published in 2018 - IPC C07D403/04 A61K31/395 A61P31/04

Abstract RU 2642882 C1

FIELD: pharmacology.

SUBSTANCE: invention relates to 3-(azol-1-yl)-6-amino substituted 1,2,4,5-tetrazines of the formula: , where Het = imidazol-1-yl, NHR = allylamino (Ia); Het = 4-methylimidazol-1-yl, NHR = allylamino (Ib); Het = benzimidazol-1-yl, NHR = allylamino (Ic); Het = indazol-1-yl, NHR = allylamino (Id); Het = imidazol-1-yl, NHR = propargylamino (Ie); Het = 4-methylimidazol-1-yl, NHR = propargylamino (If); Het = benzimidazol-1-yl, NHR = propargylamino (Ig); Het = indazol-1-yl, NHR = propargylamino (Ih). The invention also relates to antibacterial agents.

EFFECT: new compounds of formula I, active against gram-negative bacteria Neisseria gonorrhoeae and clinically relevant pathogenic and opportunistic microorganisms, are obtained.

2 cl, 2 tbl, 8 ex

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RU 2 642 882 C1

Authors

Ishmetova Rashida Irshotovna

Ignatenko Nina Konstantinovna

Belyaninova Irina Aleksandrovna

Gerasimova Natalya Avenirovna

Evstigneeva Natalya Petrovna

Zilberberg Natalya Vladimirovna

Kungurov Nikolaj Vasilevich

Rusinov Gennadij Leonidovich

Charushin Valerij Nikolaevich

Chupakhin Oleg Nikolaevich

Dates

2018-01-30—Published

2017-01-27—Filed