COMPOSITION FOR DRUG DELIVERY CONTAINING SILYL POLYMERS Russian patent published in 2020 - IPC A61K9/70 A61K31/00 A61K47/34 A61P25/34 A61P29/00 

FIELD: medicine.

SUBSTANCE: group of inventions relates to a composition and a patch for delivering medicinal agents to skin comprising: a cross-linked silyl-containing polymer and at least one medicament for delivery to skin, where silyl-containing polymer has structure in accordance with general formula (I) or (II):

formula (I)

formula (II),

where: B together with R'² represent a polymer chain of an aliphatic polyether or a polymer chain of an aliphatic polyester; R¹ is an aliphatic linear, branched or cyclic alkyl group containing 5 to 15 carbon atoms; R² independently represent a polymer chain of an aliphatic polyether; R³ denotes a divalent linear or branched alkylene group containing 1 to 10 carbon atoms; R⁴ and R⁵ are each independently selected from a linear or branched alkyl group containing 1 to 10 carbon atoms; R⁶ represents a hydrogen atom; n is an integer greater than 0; f is an integer equal to 2; and p is an integer equal to 0, 1 or 2; where n is selected such that the number average molecular weight of the polymer of formula (I) or (II) ranges from 700 Da to 250 kDa, and also relates to a method of producing the composition and use of the composition for treating diseases selected from: pain; arterial hypertension; dependencies; hormonal imbalance; cancer; bacterial, viral or fungal infections, Alzheimer's disease, mood disorders, Parkinson's disease, metabolic disorders, cicatrisation of tissues or their combinations.

EFFECT: group of inventions provides formation of thin films with excellent retention and drug delivery profile, as well as demonstrates excellent properties of adhesion and removal from skin.

34 cl, 18 dwg, 5 tbl