FIELD: cancer immunotherapy.
SUBSTANCE: isolated, ex vivo grown population of human T cells, a method for its production and pharmaceutical compositions based on it. An isolated, ex vivo grown human T cell population expresses a T cell receptor (TCR) specific HLA peptide complex containing the protein encoded by the HLA-C03:03 or HLA-C03:04 allele and the GAVGVGKSA mutant peptide; or a protein encoded by the HLA-C01:02 allele and a mutant AVGVGKSAL peptide. A method for producing a population of T cells involves priming a population of T cells with antigen presenting cells (APCs) containing a mutant RAS peptide or a polynucleotide encoding a polypeptide containing a mutant RAS peptide. RAS-specific T cells recognize mutated cells and activate the cytotoxic mechanism.
EFFECT: T cell population is suitable for the preparation of a composition for immunotherapy of cancer characterized by a RAS mutation.
15 cl, 6 dwg, 12 ex, 14 tbl
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RU2788531C2 |
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RU2779747C2 |
T-CELL RECEPTOR CONSTRUCTS AND THEIR USE | 2019 |
|
RU2785954C2 |
CONJUGATES OF ANTIBODY TO CCR7 AND DRUG | 2018 |
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RU2777662C2 |
CHIMERIC ANTIGEN RECEPTORS AND BINDING AGENTS TARGETING DLL3 | 2020 |
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RU2822366C2 |
Authors
Dates
2023-10-12—Published
2019-06-19—Filed