FIELD: pharmaceuticals.
SUBSTANCE: invention relates to benzimidazole sulfonamides of formula (I), pharmaceutically acceptable addition salts, hydrates thereof and/or solvates thereof, where L is a single bond; X is a following cyclic radical: 
; one of elements Y1, Y2, Y3, Y4 and Y5 corresponds to nitrogen atom, and other elements correspond to -CR2group, or each of elements Y1, Y2, Y3, Y4 and Y5 corresponds to -CR2 group; each of elements Q1, Q2 and Q3 corresponds to group -CR2a; R1 is a linear or branched C3-C5alkyl radical or C3-C5cycloalkyl radical; R2 represents a hydrogen atom, a linear or branched C1-C5alkyl radical or C1-C4alkoxy radical; R2a is a hydrogen atom; R3 represents a hydrogen atom or a group (CHR6)n-(Z)o-(CHR'6)p-R7; n, o and p, which can be identical or different, are zero or 1; Z is methylene group -CH2-; R6 and R'6 represent a hydrogen atom; R7 is a non-cationic heterocycloalkyl radical selected from tetrahydropyran, oxabicyclo[3.1.0]hexyl, oxetane, 2-oxo [1,3]dioxolane, 2-oxazolidinone, piperidine and 1,1-dioxo-tetrahydro-2H-thiopyrane, optionally substituted with one halogen atom, one linear or branched C1-C3alkyl group, one group S(=O)2R7a; where R7a is a linear or branched C1-C3alkyl radical; or R7 is a non-cationic unsubstituted heteroaromatic radical selected from pyridine or pyridazine; R5 represents a hydrogen atom or a linear or branched C1-C3alkyl radical. Invention also relates to a pharmaceutical composition based on the compound of formula (I).
.
EFFECT: obtaining novel benzimidazole sulfonamides, useful as reversible agonists associated with retinoids of the orphan gamma receptor (RORγt), in particular, are useful for treating acne, psoriasis, and/or atopic dermatitis.
11 cl, 3 tbl, 22 ex
| Title | Year | Author | Number |
|---|---|---|---|
| DERIVATIVES OF BENZENESULPHONAMIDES AS INVERSE AGONISTS ASSOCIATED WITH RETINOIDS ROR ORPHAN GAMMA RECEPTOR (T) | 2015 |
|
RU2724331C2 |
| SYNTHESIS OF SUBSTITUTED PYRAZOLINE CARBOXAMIDINE DERIVATIVES | 2011 |
|
RU2550694C2 |
| 5-AMINO-2-(1-HYDROXYETHYL)TETRAHYDROPYRAN DERIVATIVES | 2009 |
|
RU2525541C2 |
| SULFONAMIDE PERI-SUBSTITUTED BICYCLES FOR TREATMENT OF OCCLUSIVE AFFECTION OF ARTERIES | 2005 |
|
RU2403240C2 |
| PYRIMIDINE AMIDE COMPOUNDS AS PGDS INHIBITORS | 2006 |
|
RU2420519C2 |
| CYCLOALKYL NITRILE PYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS | 2014 |
|
RU2655380C2 |
| 2,6-SUBSTUTED-4-MONOSUBSTITUTED AMINO-PYRIMIDINES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS | 2005 |
|
RU2417990C2 |
| 2-HYDROXYETHYL-1H-QUINOLIN-2-ONE DERIVATIVES AND THEIR AZAISOSTERIC ANALOGUES WITH ANTIBACTERIAL ACTIVITY | 2010 |
|
RU2540862C2 |
| CARBOXAMIDE COMPOUNDS AND USING THEM AS CALPAIN INHIBITORS | 2010 |
|
RU2540856C2 |
| INDOLE AND INDAZOLE DERIVATIVES SHOWING PRESERVING ACTION ON CELLS, TISSUES AND ORGANS | 2009 |
|
RU2460525C2 |
