METHOD FOR INITIATION OF TUMOR CELL DEATH BY CHLORINE-E6, ASCORBIC ACID AND HF- AND SHF-ENERGY Russian patent published in 2020 - IPC A61B18/18 A61N5/00 A61P35/00 A61K41/00 C07D487/22 A61K31/375 

Abstract RU 2739252 C2

FIELD: medicine.

SUBSTANCE: invention is intended for induction of tumor cell death in living biological objects highly electroconductive solution of sodium salt of Chlorine-e6 2–3 mg/kg of body weight and ascorbic acid 200–300 mg of electromagnetic HF- and SHF-energy of photo-wave radiation, known as HF- and SHF-hyperthermia. Described is a method for initiation of tumor cell death by HF- and SHF energy, intended for local treatment of oncological patients having tumor tissues, for their hyperthermia in all organs of human body, characterized by the fact that before treatment, the person is transferred to a protein diet for 3 days for maximum saturation of oncological cells with an electron-ion solution of the chlorine-e6 sodium salt intravenously in megadose of 3.1 mg/kg of human body weight and orally in ascorbic acid megadose 500 mg of ascorbic acid is taken orally, for their maximum accumulation in tumor tissues, respectively, 3–4 times higher than in healthy tissues after 72 hours after administration of sodium chloride Chlorine-e6 and ascorbic acid 4 hours before treatment, selective hyperthermia of tumor tissues SHF-energy is performed in accordance with depth of their location and penetration depth of electromagnetic wave into human body 6.1 centimeters, at resolved frequency f=2450 MHz, with total heating rate of tumor tissues at the allowed frequency of 0.010 °C/s, for 216 seconds to heating temperature of tumor tissues 58 °C, when heating healthy tissues no more than 40 °C.

EFFECT: described method leads to thermal death of tumor tissues due to high dielectric contrast of tumor and increase in difference of its conductivity (dielectric losses) relative to surrounding healthy biological tissues, reaching multiple values for various tumors; this allows for fluorescence diagnostics to specify boundaries of tumors and to conduct simultaneous hyperthermia of tumor cells by electromagnetic HF- and SHF energy of photo-wave radiation and to detect, and destruct, therefore, even undetectable tumor formations located in deep layers of biological object.

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RU 2 739 252 C2

Authors

Tsuglenok Nikolaj Vasilevich

Dates

2020-12-22Published

2018-07-17Filed