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(19)

RU

(11)

2 739 489

(13)

C2

(51)

IPC

C07D401/14(2006-01-01)

C07D403/04(2006-01-01)

C07D471/04(2006-01-01)

C07D403/12(2006-01-01)

A61K31/4184(2006-01-01)

A61K31/437(2006-01-01)

A61K31/4709(2006-01-01)

A61K31/4375(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2018108178, 2018-03-06

(24)

Start date

2018-03-06

(22)

Actual filing date

2018-03-06

(45)

Published

2020-12-24

(72)

Inventor

Mindich Aleksej LeonidovichGorbunova Svetlana LeonidovnaPopkova Aleksandra VladimirovnaShekhovtsov Artem EvgenevichAlafinov Andrej IvanovichAleshunin Pavel AleksandrovichEvdokimov Anton AleksandrovichZavyalov Kirill VadimovichKasatkina Mariya AndreevnaKozhemyakina Natalya VladimirovnaKushakova Anna SergeevnaMaksimenko Elena AleksandrovnaMishina Mariya SergeevnaRekharskij Mikhail VladimirovichChestnova Anna YurevnaYakovlev Pavel AndreevichMorozov Dmitrij Valentinovich

(73)

Holder

Zakrytoe Aktsionernoe Obshchestvo

NOVEL HETEROCYCLIC COMPOUNDS AS CDK8/19 INHIBITORS Russian patent published in 2020 - IPC C07D401/14 C07D403/04 C07D471/04 C07D403/12 A61K31/4184 A61K31/437 A61K31/4709 A61K31/4375 A61P35/00 

Abstract RU 2739489 C2

FIELD: organic chemistry.

SUBSTANCE: present invention relates to a compound of formula I.1:

or a stereoisomer thereof, where radicals are defined in the claim. Also disclosed is a method of inhibiting the biological activity of cyclin-dependent protein kinases CDK8/19, a pharmaceutical composition, method of treating a disease or disorder, using the compound for treating a disease or disorder.

EFFECT: invention discloses novel organic compounds having CDK8/19 inhibitor properties suitable for treating an oncological or haemato-oncological disease.

16 cl, 7 tbl, 135 ex

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RU 2 739 489 C2

Authors

Mindich Aleksej Leonidovich

Gorbunova Svetlana Leonidovna

Popkova Aleksandra Vladimirovna

Shekhovtsov Artem Evgenevich

Alafinov Andrej Ivanovich

Aleshunin Pavel Aleksandrovich

Evdokimov Anton Aleksandrovich

Zavyalov Kirill Vadimovich

Kasatkina Mariya Andreevna

Kozhemyakina Natalya Vladimirovna

Kushakova Anna Sergeevna

Maksimenko Elena Aleksandrovna

Mishina Mariya Sergeevna

Rekharskij Mikhail Vladimirovich

Chestnova Anna Yurevna

Yakovlev Pavel Andreevich

Morozov Dmitrij Valentinovich

Dates

2020-12-24—Published

2018-03-06—Filed

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