FIELD: chemistry.
SUBSTANCE: present invention relates to novel N-alkyl-N-{[3-alkyl-3,8-diazabicyclo[3.2.1]octa-1(7),5-dien-8-yl]methyl}amines of general formula (1)
to a method for production thereof and to use thereof as agents with antimicrobial activity in relation to Staphylococcus aureus, Escherichia coli, Acinetobacter baumannii, Candida albicans, Cryptococcus neoformans, Klebsiella pneumoniae. Method of obtaining is that pyrrole is reacted with pre-prepared at 60 °C for 2 hours in a solution of methanol with a mixture of paraformaldehyde and an amine of general formula R-NH2, (where R is specified above), the reaction is carried out in the presence of ZrOCl2·8H2O catalyst in molar ratio of pyrrole:primary amine:paraformaldehyde:ZrOCl2·8H2O = 1:2:3:(0.03–0.07) at temperature 0 °C and atmospheric pressure for 5–7 hours.
EFFECT: disclosed are a method of producing N-alkyl-N-{[3-alkyl-3,8-diazabicyclo[3_2_1]octa-1(7),5-dien-8-yl]methyl}amines and use thereof as agents with antimicrobial activity.
3 cl, 2 tbl, 7 ex
| Title |
Year |
Author |
Number |
| N-ALKYL-N-{[3-ALKYL-3,8-DIAZABICYCLO[3_2_1]OCTA-1(7),5-DIEN-8-YL]METHYL}AMINES, HAVING CYTOTOXIC ACTIVITY ON HEK 293 CELL LINE |
2019 |
- Akhmetova Vnira Rakhimovna
- Bikbulatova Elmira Minurovna
- Akhmadiev Nail Salavatovich
- Abdullina Zilya Yamilovna
- Ibragimov Askhat Gabdrakhmanovich
- Dzhemilev Usein Memetovich
|
RU2726120C1 |
| N,N'-BIS(3-AMINOPROPYL)BUTANE-1,4-DIAMINO DERIVATIVES OF FUSIDIC ACID, HAVING A WIDE SPECTRUM OF ANTIMICROBIAL ACTIVITY |
2019 |
- Salimova Elena Viktorovna
- Tretyakova Elena Valerevna
- Parfenova Lyudmila Vyacheslavovna
|
RU2726196C1 |
| NEW NAPHTHO[2,1-B]CARBAZOL DERIVATIVES OF FUSIDIC ACID, METHOD OF SYNTHESIS AND ANTI-MICROBIAL PROPERTIES |
2019 |
- Salimova Elena Viktorovna
- Tretyakova Elena Valerevna
- Parfenova Lyudmila Vyacheslavovna
- Dzhemilev Usein Memetovich
|
RU2746947C2 |
| METHOD OF PRODUCING 1-(3-HYDROXY, 28-ACETOXY-LIP-20(29)-EN-30-YL)-PYRIDINIUM BROMIDE AND USE THEREOF AS AN AGENT WITH ANTIBACTERIAL AND ANTIFUNGAL ACTIVITY |
2018 |
- Parfenova Lyudmila Vyacheslavovna
- Shakurova Elvira Rifovna
- Ponedelkina Irina Yurevna
|
RU2725873C2 |
| (1-BENZYL-1H-1,2,3-TRIAZOL-4-YL)METHYL (Z)-2-((3S,4S,8S,10S,11R,14S,16S)-16-ACETOXY-3,11 -DIHYDROXY-4,8,10,14-TETRAMETHYLHEXADECAHYDRO-17H-CYCLOPENTA[a]PHENANTHRENE-17-YLIDENE)-6-METHYLHEPT-5-ENOATE EXHIBITING ANTIBACTERIAL AND FUNGICIDAL ACTIVITY |
2022 |
- Salimova Elena Viktorovna
- Parfenova Liudmila Viacheslavovna
|
RU2784215C1 |
| (2Z)-2-[(3Β, 4Α, 8Α, 11Α, 14Β, 16Β)-16-(ACETYLOXY)-3-({3-[(4-AMINOBUTYL)AMINO]PROPYL}AMINO)-11-HYDROXY-4,8,10,14-TETRAMETHYL GONANE-17-YLIDENE]-6-METHYLHEPT-5-ENOIC ACID WITH ANTIMICROBIAL AND FUNGICIDAL ACTIVITY AND METHOD FOR PRODUCTION THEREOF |
2019 |
- Salimova Elena Viktorovna
- Tretyakova Elena Valerevna
- Parfenova Lyudmila Vyacheslavovna
|
RU2730604C1 |
| METHOD OF PRODUCING BINUCLEAR N,O-COMPLEXES OF DIACETATE MONOHYDRATE (DIHYDRATE DICHLORIDE, DIBROMIDE) COPPER (II) WITH 1-[(DIMETHYLAMINO) METHYL]-2-NAPHTHOL, HAVING FUNGICIDAL ACTIVITY |
2019 |
- Akhmetova Vnira Rakhimovna
- Bikbulatova Elmira Minurovna
- Akhmadiev Nail Salavatovich
- Abdullina Zilya Yamilovna
- Ibragimov Askhat Gabdrakhmanovich
- Dzhemilev Usein Memetovich
|
RU2726651C1 |
| APPLICATION OF 9-BENZOYL-8-HYDROXY-6-(2-HYDROXY-5-CHLOROPHENYL)-2-PHENYL-1-THIA-3,6-DIAZASPIRO[4.4]NONA-2,8-DIENE-4,7-DIONE AS AN ANTIFUNGAL AGENT AGAINST CRYPTOCOCCUS NEOFORMANS |
2022 |
- Maslivets Andrei Nikolaevich
- Khramtsova Ekaterina Evgenevna
|
RU2790377C1 |
| METHOD FOR PREPARATION OF N-ALKYL-O-ALKYL URETHANES |
2007 |
- Mantrov Sergej Nikolaevich
- Orlova Aleksandra Anatol'Evna
- Chimishkjan Aleksandr Leonovich
|
RU2359958C2 |
| METHOD FOR PREPARING N-ALKYL-N, N-DI (ALKADIENYL) AMINES |
2015 |
- Dzhemilev Usein Memetovich
- Ibragimov Askhat Gabdrakhmanovich
- Khabibullina Guzel Razhapovna
- Zajnullina Firuza Timiryanovna
- Yakupova Liliya Rafikovna
|
RU2626008C2 |
