FIELD: biotechnology.
SUBSTANCE: described is a group of inventions including an adenovirus system for treating cancer, an anti-cancer composition including the above adenovirus system, and a composition for enhancing the anti-tumour immunity including the above adenovirus system. In one of the implementations, the adenovirus system contains a gene encoding interleukin-12 (IL-12); and a gene expressing an oligonucleotide complementary to C-met (Met tyrosine kinase) mRNA and inhibits C-met expression.
EFFECT: invention expands the range of anticancer products.
15 cl, 22 dwg, 2 tbl, 16 ex
| Title |
Year |
Author |
Number |
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2012 |
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2009 |
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2018 |
|
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2017 |
|
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| ONCOLYTIC ADENOVIRUS FOR TREATING CANCER, USING IT, AND PHARMACEUTICAL COMPOSITION CONTAINING IT |
2010 |
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|
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| ADENOVIRUS CONTAINING ALBUMIN-BINDING SITE |
2015 |
- Alemany Bonastre, Ramon
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|
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| COMBINATION THERAPY USING REIC/DKK-3 GENE AND IMMUNE RESPONSE CHECKPOINT INHIBITOR |
2017 |
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RU2767997C2 |
| DESIGNING OF CARCINOLYTIC ADENOVIRUS RECOMBINANT, SPECIFICALLY EXPRESSING IMMUNOMODULATORY FACTOR GM-CSF IN TUMORAL CELLS AND ITS APPLICATION |
2004 |
|
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| VECTORS CONDITIONALLY EXPRESSING THERAPEUTIC PROTEINS, HOST CELLS COMPRISING THE VECTORS, AND USES THEREOF |
2011 |
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RU2612788C2 |
