FIELD: medicine, pharmaceutics.
SUBSTANCE: recombinant adenovirus, a pharmaceutical composition containing this virus, and a method of treating cancer with using this virus are presented. The characterised recombinant adenovirus containing a polynucleotide coding a complex of trans-splicing mediating rybozyme, and HSVtk (herpes simplex virus thymidine kinase), wherein the trans-splicing mediating rybozyme represents rybozyme Rib67, and wherein a trans-splicing mediating rybozyme target is cancer-specific TERT (telomerase reverse transcriptase) gene mRNA and an anti-cancer therapeutic gene coding sPD-1 (soluble programmed dead protein 1). The recombinant adenovirus possesses cancer cell selectivity caused by the trans-splicing mediating rybozyme, and enhanced anti-cancer activity caused by the anti-cancer therapeutic gene.
EFFECT: presented inventions can be used for the effective prevention and treatment of cancer.
5 cl, 23 dwg, 13 ex
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