METHOD FOR PREDICTION OF REPEATED RESPIRATORY INFECTIONS IN CHILDREN Russian patent published in 2021 - IPC A61B5/00 G01N33/487 G01N30/12 G01N33/92 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to paediatrics, and can be used for prediction of repeated respiratory infections in children. Content of acetic, propionic, isobutyric, butyric, isovaleric, valeric and capronic acids is determined in the child's saliva by gas-liquid chromatography. Using the linear discriminant analysis, the prognostic coefficients are calculated, which estimate the possibility of assigning the patient to the risk group of repeated respiratory infections by the formulas: for the acute period of acute respiratory infections: F₁=1368.494*C2+1538.684*C3+7103.235*iC5+2165.619*C5-683.304, F₂=1403.533*C2+1583.797*C3+7338.304*iC5+2241.567*C5-719.622; for the ARI remission period: F₁=48.2003*iC4-5.8212*C4+49.1095*iC5+369.9298*C6-2.4024, F₂=129.961*iC4+29.9281*C4-61.2817*iC5+73.5953*C6-1.9865, where C2 is relative concentration of acetic acid; C3 is relative concentration of propionic acid; iC4 is isobutyric acid relative concentration; C4 is the relative concentration of butyric acid; iC5 is relative concentration of isovaleric acid; C5 is the relative concentration of valeric acid; C6 is relative concentration of caproic acid. If F₁ is more than F₂, the patient's ratio to the risk of recurrent respiratory infections is predicted. If F₁ is less than F₂, the ratio of the patient to the risk group of repeated respiratory infections is not predicted.

EFFECT: method enables predicting repeated respiratory infections in children by using a metabolic imprint of oropharynx microbiocenosis, that is a microbiota reaction and a change in metabolic pathways of substrate fermentation.

1 cl, 3 ex