FIELD: medicine.
SUBSTANCE: group of inventions relates to a combined antiallergic drug for nasal application for treating acute rhinitis, allergic rhinitis, vasomotor rhinitis, chronic rhinitis, sinusitis, as an auxiliary method for otitis treatment, in preparation for nasal surgeries, for elimination of mucous membrane edema of nasal cavity and paranasal sinuses after surgical interventions in this area, comprising phenylephrine or a pharmaceutically acceptable salt thereof and cetirizine or a pharmaceutically acceptable salt thereof, as well as a pharmaceutically acceptable solvent, a humectant, a preserving agent, a buffer, a complexing agent, characterized by that the ratio of phenylephrine or phenylephrine hydrochloride and cetirizine or cetirizine hydrochloride is 1:1 with the following content of components, wt %: phenylephrine or phenylephrine hydrochloride 0.05–1.05; cetirizine or cetirizine hydrochloride 0.05–1.05; humidifier 0.0015–8.5; preserving agent 0.005–0.3; buffer 0.02–1.1; complexing agent 0.005–0.1; solvent—balance, and also relates to a combined antiallergic drug for nasal application for treating acute rhinitis, allergic rhinitis, vasomotor rhinitis, chronic rhinitis, sinusitis, as an auxiliary method for otitis treatment, in preparation for nasal surgeries, for eliminating edema of the nasal mucosa and paranasal sinuses after surgical interventions in this region, containing phenylephrine or phenylephrine hydrochloride and cetirizine or cetirizine hydrochloride, as well as a pharmaceutically acceptable humectant, a preserving agent, a buffer, complexing agent, characterized by that the ratio of phenylephrine or phenylephrine hydrochloride and cetirizine or cetirizine hydrochloride is 1:1 with the following components in 1 ml of the drug, mg: phenylephrine or phenylephrine hydrochloride 0.5–10.5; cetirizine or cetirizine hydrochloride 0.5–10.5; humidifier 0.015–85.0; preservative 0.05–3.0; pharmaceutically acceptable buffer 0.2–11; complexing agent 0.05–1.0; solvent is the rest.
EFFECT: group of inventions provides high therapeutic effect (anti-inflammatory, anti-edema, antihistaminic) and increased storage life, and also provides a risk of side effects and complications.
5 cl, 1 tbl
