FIELD: biochemistry.
SUBSTANCE: present invention relates to novel methods for synthesizing 1-(4-methanesulfonyl-2-trifluoromethyl-benzyl)-2-methyl-1H-pyrrolo [2,3-b] pyridin-3-yl-acetic acid and to intermediate products which are used in such methods. In particular, the invention relates to a novel formula (C6) compound and to a method for producing said method, which comprises (a) the interaction of a formula (C4) compound with a formula (C5) compound in the presence of a catalyst, a reducing reagent and one or more solvents, selected from a group consisting of ethanol, toluene, raw toluene, isopropyl acetate and mixtures thereof. The invention also relates to a method for producing a formula (C8) compound.
EFFECT: invention enables effective production of said acid.
18 cl, 6 ex
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|
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|
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|
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