FIELD: chemistry.
SUBSTANCE: invention relates to methods for producing 1-(4-methanesulfonyl-2-trifluoromethylbenzyl)-2-methyl-1H-pyrrolo[2,3-b]pyridine-3-yl-acetic acid (Compound A). The first producing method consists in the interaction of a compound of the formula C9 with dimethyl ether of diazomalonic acid (DMDA) in the presence of a catalyst and an organic solvent to form a compound of the formula C10. Then, a reaction of the compound of the formula C10 with a strong base/acid is carried out to obtain the Compound A. The second synthesis method includes a reaction of the compound of the formula C9 with halogen to form a compound of the formula C11. The resulting compound of the formula C11 is subjected to interaction with dimethylmaleate to form the compound of the formula C10, which is converted into the Compound A by the above-mentioned method.
EFFECT: methods consist of a smaller number of stages, allow one to achieve higher yield of the product and have higher selectivity for the Compound A.
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, 
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18 cl, 1 dwg, 37 ex
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