PHARMACEUTICAL COMPOSITION INCLUDING DORSOLAMIDE AND BRIMONIDINE Russian patent published in 2021 - IPC A61K9/08 A61K31/382 A61K31/498 A61K47/04 A61K47/18 A61P27/06 

FIELD: medicine.

SUBSTANCE: invention relates to a preservative pharmaceutical composition for glaucoma or ocular hypertension treatment, which comprises dorsolamide or its pharmaceutically acceptable salt and brimonidine or its pharmaceutically acceptable salt, does not contain a preservative other than edetic acid or its salt selected from the group which includes edetate monosodium, edetate disodium and edetate tetrasodium, and boracic acid or its salt selected from group consisting of borax, sodium borate and potassium borate, where: edetic acid or its salt mass content varies from 0,001% mass/vol to 0,1% mass/vol; boracic acid or its salt content varies from 0,001% mass/vol to 3% mass/vol; and pH is 6.0 or more. Present invention also relates to eye drops for glaucoma or ocular hypertension treatment, to the preservative pharmaceutical composition usage, and to a method for increasing preservative effectiveness.

EFFECT: receiving a composition with a sufficient preservative effect.

14 cl, 1 tbl, 2 ex