PHARMACEUTICAL COMPOSITIONS POSSESSING DESIRABLE BIOAVAILABILITY Russian patent published in 2014 - IPC A61K31/192 A61K31/5575 A61P27/06 

FIELD: medicine, pharmaceutics.

SUBSTANCE: present invention refers to chemical-pharmaceutical industry and represents an ophthalmic pharmaceutical composition containing: an amount of prostaglandine applicable for treating glaucoma; a polymer compound of quarternary ammonium for preserving the composition; a surfactant, wherein the surfactant is ethoxylated and/or hydrogenated vegetable castor oil in the concentration of at least 0.05 wt/vol %, but not less than 0.4 wt/vol % of the composition, wherein i) the surfactant representing the ethoxylated and/or hydrogenated vegetable castor oil is the one surfactant in the composition fully or substantially fully; and ii) the composition is free from benzalkonium chloride; and water, wherein the composition is applicable locally on an individual's eye.

EFFECT: invention provides the better bioavailability of the composition and the reduced amount of the surfactant.

17 cl, 6 dwg