PHARMACEUTICAL COMPOSITIONS OF ATROPINE Russian patent published in 2021 - IPC A61K31/46 A61K47/02 A61K47/18 A61K47/38 A61K9/00 A61K9/08 A61P27/02 A61P27/10 

FIELD: pharmaceuticals.

SUBSTANCE: present invention relates to the pharmaceutical industry, namely to a liquid storage-stable ophthalmologic composition with a low atropine dosage (variants), to a method of manufacture of a storage-stable liquid ophthalmologic composition with a low atropine dosage and a method of increasing stability thereof, to a kit for treatment of myopia. The liquid storage-stable ophthalmologic composition with a low atropine dosage contains a water solution containing a buffer at a concentration equal to or less than 75 mM, a tonicity regulator, a viscosity modifier, a chelator and atropine or a pharmaceutically acceptable salt thereof at a low dosage, wherein the ophthalmologic composition of atropine has a pH of 5.0 to 6.0; wherein the ophthalmologic composition of atropine is essentially free of preservatives (variants).

EFFECT: described invention allows producing liquid storage-stable ophthalmologic composition with a low atropine dosage with improved stability and a physiologically acceptable pH, wherein the compositions contain a low level of tropaic acid from degradation of atropine (less than 0.35%) and are also essentially devoid of preservatives.

109 cl, 1 dwg, 28 tbl