COMPOSITIONS AND METHODS OF USING CHOLINE ESTER OF LIPOIC ACID Russian patent published in 2020 - IPC A61K31/385 A61K47/10 A61P27/10 

FIELD: pharmaceutical industry.

SUBSTANCE: group of inventions refers to a pharmaceutical composition for improving the amplitude of accommodation of a lens or for treating or preventing presbyopia in a subject, which contains (in wt % of weight of composition): choline ester of lipoic acid (1–10 %), non-aqueous excipient selected from glycerine (0.1–5 %) or mixture of glycerine and propylene glycol (0.5–5 %), and alanine (0.1–5 %), where said components are mixed with aqueous solution having pH from 4 to 6. Also disclosed are a method of improving the amplitude of lens accommodation and a method of treating or preventing presbyopia in a subject, comprising a step, on which an effective amount of the declared pharmaceutical composition is respectively introduced into the lens of eye or eye of the subject.

EFFECT: group of inventions provides stability of composition during storage (at least 95 % of the initial amount of choline ester of lipoic acid is present in the composition by HPLC after storage at 25 °C and 40 % relative humidity for 3 months).

9 cl, 10 ex, 13 tbl, 5 dwg