FIELD: biotechnology.
SUBSTANCE: present invention provides an immunogenic polypeptide comprising a plurality of N-terminal L2 papilloma virus (HPV) peptides corresponding to amino acids 20–50 of the HPV16 L2 polypeptide, wherein said N-terminal peptides of L2 HPV are N-terminal L2 peptides from at least two different HPV genotypes. Present invention also provides the above immunogenic polypeptide for use in medicine and for use in vaccinating against HPV infection. In addition, the present invention provides a polynucleotide encoding an immunogenic polypeptide and a host cell comprising said polynucleotide. Invention also provides kits, methods and applications associated with the immunogenic polypeptide according to the present invention.
EFFECT: improved immunogenicity of HPV peptide L2.
16 cl, 8 dwg, 3 ex
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