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2 747 202

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IPC

A61K31/343(2006-01-01)

A61P9/10(2006-01-01)

C07D307/91(2006-01-01)

(21) (22)

Application

2019134302, 2019-10-25

(24)

Start date

2019-10-25

(22)

Actual filing date

2019-10-25

(45)

Published

2021-04-29

(72)

Inventor

Mirzoyan Ruben SimonovichGanshina Tamara SergeevnaKurza Elena VladimirovnaKurdyumov Ilya NikolaevichTurilova Antonina IvanovnaZhmurenko Lyudmila MikhajlovnaMaslennikov Denis VadimovichKovalev Georgij IvanovichVasileva Ekaterina Vasilevna

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Nauchnoe Uchrezhdenie Institut Farmakologii Imeni V.V. Zakusova"

DRUG FOR IMPROVING BLOOD SUPPLY OF ISCHEMIZED BRAIN Russian patent published in 2021 - IPC A61K31/343 A61P9/10 C07D307/91

Abstract RU 2747202 C2

FIELD: pharmaceutical industry.

SUBSTANCE: invention relates to the use of O-(4-cinnamoyl)oxime 3,4,6,7,8,9-hexahydrodibenzo [b, d] furan-1 (2H) -one (C21H21NO3) - GIZH-272 as a treatment cerebral circulation disorders. GIZH-272 is able to improve blood supply to the brain in the model of global transient ischemia. In a hemorrhagic stroke model, the compound also increases blood flow in the rat cerebral cortex. The compound has a pronounced cerebrovascular anti-ischemic activity, not inferior in strength to mexidol and exceeding the duration of action of nimodipine. In addition, GIZH-272 does not lower blood pressure, which compares favorably with Mexidol and Nimodipine.

EFFECT: compound simultaneously exhibits cerebrovascular and anticonvulsant properties and can be useful both in treatment of patients with cerebrovascular diseases, which are combined or complicated by convulsive manifestations, and in patients with convulsive disorders, which are accompanied by cerebrovascular accidents.

1 cl, 4 tbl, 2 ex, 2 dwg

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RU 2 747 202 C2

Authors

Mirzoyan Ruben Simonovich

Ganshina Tamara Sergeevna

Kurza Elena Vladimirovna

Kurdyumov Ilya Nikolaevich

Turilova Antonina Ivanovna

Zhmurenko Lyudmila Mikhajlovna

Maslennikov Denis Vadimovich

Kovalev Georgij Ivanovich

Vasileva Ekaterina Vasilevna

Dates

2021-04-29—Published

2019-10-25—Filed