CHELATED COMPOUNDS Russian patent published in 2021 - IPC C07D471/08 C07F13/00 A61K49/10 

FIELD: chemistry.

SUBSTANCE: present invention relates to a compound of Formula I:

,

In which R¹ is independently selected from a group including С_1-20 hydroxyalkyl, C_1-6 alkyl, С_3-6 aril, optionally substituted with one or more substituents selected from halogen and -C(=O)-NH-C_1-6 hydroxyalkyl; each R² is independently selected from a group including C_1-20 hydroxyalkyl, C_1-6 alkyl or hydrogen; R³ is selected from a group including С_1-3 alkyl or -(CH₂)_m-C(=O)-NR⁵R⁶, in which m is an integer from 2 to 5, and R⁵ and R⁶ are such as, respectively, specified for R¹ and R²; R⁴ is missing; each n is an integer from 0 to 4; and the compound of Formula I contains at least two hydroxy groups. A method for obtaining a compound of Formula I, a method for obtaining an intermediate compound of Formula II, a pharmaceutical composition, and a method for obtaining MR images and/or MR spectra are also proposed.

EFFECT: proposed compounds have improved and long-term kinetic stability while maintaining suitable relaxation properties and can be used as contrast agents in magnetic resonance imaging (MRI).

44 cl, 11 dwg, 5 tbl, 15 ex