MEDICINAL FORMS FOR EXTERNAL USE CONTAINING CYCLOSPORINE AND USE THEREOF Russian patent published in 2021 - IPC A61K38/13 A61P27/02 

FIELD: medicine.

SUBSTANCE: group of inventions relates to the field of medicine, namely to ophthalmology, and is intended for treatment or prevention of keratoconjunctivitis sicca. Ophthalmological pharmaceutical form for external use includes cyclosporine; one or more from HCO-40, HCO-60, HCO-80, and HCO-100; and octoxynol-40. The components are used in the proposed amounts in accordance with different implementation variants of the pharmaceutical form. In other embodiments, methods of production of said ophthalmological pharmaceutical form are executed. Also proposed is a method of treatment or prevention of keratoconjunctivitis sicca including external administration of the described ophthalmological pharmaceutical form for external use to a subject in need thereof.

EFFECT: use of the group of inventions allows for a better safety profile and does not cause development of side effects such as decreased vision acuity, blurred vision, increased tear secretion, eye discharge and dysadhesion, and also allows increasing long-term stability, which in turn increases efficiency of treatment or preventing of keratoconjunctivitis sicca.

19 cl, 5 ex, 1 dwg