1,3,4-OXADIAZOLE DERIVATIVES AS HISTONE DEACETYLASE 6 INHIBITOR AND PHARMACEUTICAL COMPOSITION CONTAINING THEREOF Russian patent published in 2024 - IPC C07D471/04 A61K31/4545 A61K31/496 A61P35/00 A61P29/00 A61P25/00 A61P37/00 

FIELD: chemistry.

SUBSTANCE: invention relates to 1,3,4-oxadiazole derivative of formula I, where L₁, L₂ and L₃ each independently represents -(C₀-C₂ alkyl)-; a, b and c each independently represents CR⁴, {where R⁴ is -H}; R₁ is -CF₂H or CX₃; R₂ represents structures (a), (b), (c); Y is -N-; when Y is -N-, R₅, R₆ and R₈ each independently represents -(C₁-C₄ alkyl), -(C₃-C₇ cycloalkyl), -(C₂-C₆ heterocycloalkyl) containing an O atom in the ring, -CF₃, -CF₂H, -C(=O)-(C₁-C₄ alkyl), -C(=O)-(C₃-C₇ cycloalkyl), -C(=O)-(C₂-C₆ heterocycloalkyl), containing one O atom in the ring, -C(=O)-O(C₁-C₄ alkyl), -C(=O)-NR^CR^D, -S(=O)₂-(C₁-C₄ alkyl), -C₄-C₅heteroaryl, containing one or two N atoms in the ring, or structure (d), wherein at least one H of -(C₁-C₄ alkyl), -(C=O)-(C₁-C₄ alkyl) and -(C₃-C₇ cycloalkyl) can be substituted with -X or -OH; Z is -CH₂- or -O-; R^C - R^D each independently represents -(C₁-C₄ alkyl); m and n are each independently an integer selected from 1 or 2; R_a-R_d each independently represents -H; R³ is -C₆aryl, wherein at least one H of -C₆ aryl can each independently be substituted with -X; X is F, Cl, Br or I. Invention also relates to a pharmaceutical composition having histone deacetylase 6 inhibiting activity, containing as an active ingredient a therapeutically effective amount of a compound of formula I or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier, a method of inhibiting histone deacetylase 6 and use of a compound of formula I for preparing a drug for inhibiting histone deacetylase 6.

EFFECT: compound of formula I, having selective inhibitory activity on histone deacetylase 6 (HDAC6).

12 cl, 4 tbl, 84 ex