SYNERGIC COMPOSITION TO MAINTAIN HEALTHY BALANCE OF MICROFLORA Russian patent published in 2021 - IPC A61K31/7004 A61K31/715 A61K31/198 A61K31/7068 A61P15/02 A61P17/00 

FIELD: pharmaceutical industry.

SUBSTANCE: group of inventions relates to the pharmaceutical industry, namely to a composition for maintaining a healthy balance of microflora in the urogenital area. Disclosed is a composition for maintaining a healthy balance of microflora in the urogenital area, including: the first therapeutic agent containing α-methyl-D-glucoside; and the second therapeutic agent containing a nitrogen-containing compound, wherein the nitrogen-containing compound is selected from the group consisting of L-cysteine, cytidine, D-asparagine, pyrimidine, D-alanine, D-glucosamine HCL and N-acetyl-D-glucosamine, where the total the amount of said α-methyl-D-glucoside and said nitrogen-containing compound is from 0.1 to 10% w / v, and wherein the weight ratio of the first therapeutic agent to the second therapeutic agent is from 1:1 to 10:1. Disclosed is a composition for maintaining a healthy balance of microflora in the urogenital area, including: the first therapeutic agent containing α-methyl-D-glucoside; and the second therapeutic agent containing a nitrogen-containing compound, wherein the nitrogen-containing compound is selected from the group consisting of: alloxan, ammonium citrate, glycine, L-cysteine, L-glutamic acid, L-glutamine, L-homoserine, L-leucine, L- lysine, L-methionine, cytidine, D-asparagine, adenosine, H-Ala Thr-OH, D-glucuronamide, Ala-Asp, Ala-His, Gly-Met, N-acetyl-D-galactosamine, pyrimidine, L-serine, inosine, D-alanine, N-acetyl-D-mannosamine, Gly-Asn, Ala-Glu, HCL D-galactosamine, HCL D-glucosamine, DL-a-amino-n-butyric acid, HCl D-mannosamine, Gly -Gln, Gly-Glu, DL-lactamide, Met-Ala, methyl (2-phenylethyl) amine hydrochloride, glycyl-alanine, DL-gamma-amino-n-butyric acid and N-acetyl-D-glucosamine; where the total amount of said α-methyl-D-glucoside and said nitrogen-containing compound is from 0.1 to 10% w / v and where the weight ratio of the first therapeutic agent to the second therapeutic agent is from 2:1 to 10:1. Disclosed is a composition for maintaining a healthy balance of microflora in the urogenital area, including: the first therapeutic agent containing α-methyl-D-glucoside; and the second therapeutic agent containing a nitrogen-containing compound, the nitrogen-containing compound being selected from the group consisting of glycine, L-cysteine, L-ornithine, cytidine, D-asparagine, pyrimidine, D-alanine, HCL D-glucosamine, DL-a- amino-n-butyric acid, methyl (2-phenylethyl) amine hydrochloride and N-acetyl-D-glucosamine; where the total amount of said α-methyl-D-glucoside and said nitrogen-containing compound is from 0.1 to 10% w / v and where the weight ratio of the first therapeutic agent to the second therapeutic agent is from 1:1 to 2:1.

EFFECT: disclosed is a method for maintaining a healthy balance of microflora in the urogenital region of a patient in need thereof. The method involves the local introduction of the composition into the urogenital area of the patient. The above compositions and method are effective for maintaining a healthy microflora balance in the urogenital region of a patient.

12 cl, 2 tbl, 27 ex