METHOD FOR PREVENTIVE GENE THERAPY FOR SUPPRESSING NEURON DEATH IN ISCHEMIC BRAIN STROKE Russian patent published in 2021 - IPC A61K31/7088 A61K48/00 A61P9/10 A61P43/00 

FIELD: medicine.

SUBSTANCE: invention relates to medicine and is intended for preventive gene therapy of ischemic stroke. A therapeutically effective dose of a neuron death inhibiting agent constituting genetic material consisting of three recombinant human genes, namely the vascular endothelial growth factor gene VEGF, the glial cell derived neurotrophic factor gene GDNF and the neuronal cell adhesion molecule gene NCAM, are directly administered by intrathecal injection prior to the onset of insult as part of adenoviral vectors at a rate of 2x10⁷ viral particles in 20 mcl of saline or on cell carriers at a rate of 2x10⁶ cells in 20 mcl of saline wherein the multiplicity of cell infection by neuron death inhibition equals 10.

EFFECT: invention ensures production of a medicinal product with a property of increasing viability of neurons in case of a threat of an ischemic brain stroke.

1 cl, 2 ex