PHARMACEUTICAL COMPOSITION AND METHOD FOR USING THE SAME FOR THE TREATMENT OF BRAIN AND SPINAL CORD INJURIES Russian patent published in 2022 - IPC A61K48/00 A61K35/12 A61P9/10 A61P25/02 

FIELD: medicine.

SUBSTANCE: inventions group relates to medicine and pharmaceuticals and can be used for neurorehabilitation of patients after ischemic stroke, neurotrauma and with neurodegenerative diseases. The proposed is a pharmaceutical composition for therapy for injuries of the brain and spinal cord, containing an adenoviral vector based on human adenovirus serotype 5 with fiber 35 serotype, containing the coding sequence of the human VEGF165 gene represented by SEQ ID NO: 1, an adenoviral vector based on human adenovirus 5 serotype with fiber 35 serotype containing the coding sequence of the human GDNF gene shown by SEQ ID NO: 2, an adenoviral vector based on human adenovirus 5 serotype with fiber 35 serotype containing the coding sequence of the human NCAM gene shown by SEQ ID NO: 3, as well as a pharmaceutically acceptable buffer solution . Also disclosed are a method for producing a leukoconcentrate enriched with genetic material, the use of this leucoconcentrate as part of the complex therapy for brain and spinal cord injuries, and a method for treating brain and spinal cord injuries in a patient.

EFFECT: efficient cell-mediated gene therapy for ischemic and traumatic injuries of the brain and spinal cord is provided.

14 cl, 8 dwg, 4 ex