FIELD: biotechnology.
SUBSTANCE: invention relates to the field of biotechnology, in particular to an epigenome repressor of the transcription of gene or genes in human cells, excluding human germ line cells, which is a dCas9 protein linked by a linker to the DNMT3a-L protein, which is linked by a linker to the KRAB repressor domain, which is linked by a linker to the MeCP2 protein.
EFFECT: invention is effective for scientific experiments in the field of fundamental cell biology, biomedical research in the modeling of hereditary diseases, as well as in treatment of hereditary diseases.
1 cl, 3 dwg
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