METHOD OF INCREASING CONSISTENCY OF INTESTINAL ANASTOMOSIS USING BIORESORBABLE TUBE BASED ON METACRYLATED GELATIN AND METACRYLATED FIBROIN Russian patent published in 2021 - IPC A61F2/02 A61F2/04 A61K38/17 A61L27/22 A61F2/82 A61B17/03 A61B17/11 A61K35/64 

FIELD: biotechnology.

SUBSTANCE: invention relates to biotechnology and medicine, namely to the field of surgery, and discloses a method of increasing consistency of intestinal anastomosis. The method involves the use of a biodegradable implant based on methacrylated silk fibroin and includes obtaining a bioresorbable tube, multiple incubation of the tube in a sterile saline solution for 15 to 30 minutes with replacement of the saline solution, preparation of experimental animals by feeding with 10% glucose solution without limitation for 2 whole days, closing the anastomosis with the tube on experimental animals, postoperative care by daily injections of ceftriaxone. Aside from mechanical protection of the anastomosis area the method allows for active integration of the implant into the regeneration process. The implant becomes the basis for the regeneration of the intestinal wall.

EFFECT: in experimental studies on rats complete regeneration of the intestinal wall with preservation of the architectonics and organ function is shown.

14 cl, 3 dwg, 2 ex