FIELD: pharmacology; medicine; chemical and pharmaceutical industry.
SUBSTANCE: invention relates to pharmacology, medicine and chemical and pharmaceutical industry, namely to a new local application of dioxidine (hydroxymethylquinoxalinedioxide) in the form of 0.001-0.4% wt./vol. of an aqueous solution with a pH of 3 to 7.5, where dioxidine acts as an agent, for the treatment and/or prevention of infectious and inflammatory diseases of the oral cavity and pharynx, such as stomatitis and gingivitis. The above-mentioned dioxidine solution can be used as a spray or liquid for rinsing or cleaning the oral cavity and pharynx, or in the form of drops. The use of such a dioxidine solution in the oral cavity is characterized by the absence of a side effect in the form of nausea and vomiting in case of accidental ingestion, which can be observed with the use of known dioxidine solutions (with a concentration of 0.5% and 1%).
EFFECT: use of dioxidine in an aqueous solution with a concentration and pH in the above-mentioned ranges provides an increase in the photostability and resistance to self-oxidation of dioxidine in solution compared to known dioxidine solutions, an increase in the quality of dioxidine solutions and their safety due to the absence of microcrystals in them.
24 cl, 5 tbl, 6 ex
