FIELD: biochemistry.
SUBSTANCE: invention relates to the field of biochemistry, in particular to a method for producing a culture containing megakaryocytes or megakaryocytic progenitor cells having an increased ability to produce platelets. Also disclosed is a method for producing platelets, as well as a method for expanding a culture by megakaryocytes or megakaryocytic progenitor cells having an increased ability to produce platelets. The invention also relates to the use of a drug exhibiting cytotoxicity for the production of a culture containing megakaryocytes or megakaryocytic progenitor cells having increased platelet productivity per cell.
EFFECT: invention makes it possible to effectively obtain megakaryocytes or megakaryocytic progenitor cells with an increased ability to produce platelets.
13 cl, 10 dwg, 2 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| NOVEL METHOD FOR PRODUCING DIFFERENTIATED CELLS | 2010 |
|
RU2661107C1 |
| METHOD FOR PRODUCING POLYPLOIDIZED MEGAKARYOCYTE AND PLATELETS | 2012 |
|
RU2606764C2 |
| NOVEL METHOD FOR PRODUCING DIFFERENTIATED CELLS | 2010 |
|
RU2603094C2 |
| METHOD OF OBTAINING A STEM CELL CLONE SUITABLE FOR INDUCING DIFFERENTIATION INTO SOMATIC CELLS | 2016 |
|
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| METHOD FOR THE PRODUCTION OF PLATELETS BY A METHOD FOR ROTATIONAL MIXING OF THE CULTURE | 2016 |
|
RU2756000C2 |
| METHOD OF PRODUCING THROMBOCYTES BY MEANS OF DEVICE FOR BACK-AND-FORTH STIRRING | 2016 |
|
RU2741871C2 |
| METHOD FOR PRODUCING HIGH-FUNCTION THROMBOCYTES | 2016 |
|
RU2724533C2 |
| REPROGRAMMING HUMAN ENDOTHELIUM IN HEMATOPOIETIC PRECURSORS OF MULTIPLE LINES OF DIFFERENTIATION USING CERTAIN FACTORS | 2014 |
|
RU2691062C2 |
| METHOD FOR PRODUCING PURIFIED THROMBOCYTES | 2016 |
|
RU2766177C2 |
| COMPOSITION FOR SUPPORTING FUNCTION OF PLATELETS | 2011 |
|
RU2578607C2 |
