FIELD: biotechnology.
SUBSTANCE: invention refers to producing thrombocytes and an agent promoting the production of PAC-1-positive thrombocytes. Method involves contacting with megakaryocytes or precursor cells thereof, containing one or more aryl-hydrocarbon receptor (AhR) antagonists and one or more Rho-associated super-spiral-forming kinase (ROCK) inhibitors.
EFFECT: invention widens the range of equipment.
12 cl, 21 dwg, 1 tbl, 1 ex
Title | Year | Author | Number |
---|---|---|---|
METHOD FOR PRODUCING POLYPLOIDIZED MEGAKARYOCYTE AND PLATELETS | 2012 |
|
RU2606764C2 |
METHOD FOR THE PRODUCTION OF PLATELETS BY A METHOD FOR ROTATIONAL MIXING OF THE CULTURE | 2016 |
|
RU2756000C2 |
METHOD FOR OBTAINING CULTURE CONTAINING MEGAKARYOCYTES AND METHOD FOR OBTAINING PLATELETS WITH ITS APPLICATION | 2016 |
|
RU2750740C2 |
METHOD FOR PRODUCING PURIFIED THROMBOCYTES | 2016 |
|
RU2766177C2 |
NOVEL METHOD FOR PRODUCING DIFFERENTIATED CELLS | 2010 |
|
RU2661107C1 |
METHOD OF PRODUCING THROMBOCYTES BY MEANS OF DEVICE FOR BACK-AND-FORTH STIRRING | 2016 |
|
RU2741871C2 |
METHOD OF OBTAINING A STEM CELL CLONE SUITABLE FOR INDUCING DIFFERENTIATION INTO SOMATIC CELLS | 2016 |
|
RU2730034C2 |
NOVEL METHOD FOR PRODUCING DIFFERENTIATED CELLS | 2010 |
|
RU2603094C2 |
COMPOSITION FOR SUPPORTING FUNCTION OF PLATELETS | 2011 |
|
RU2578607C2 |
CONVERSION OF SOMATIC CELLS INTO INDUCED REPROGRAMMED NEURAL STEM CELLS (IRNSC) | 2011 |
|
RU2562111C2 |
Authors
Dates
2020-06-23—Published
2016-06-16—Filed