FIELD: amfamide preparation.
SUBSTANCE: invention relates to a method for the preparation of N-(2-aminoethyl)amide of amphotericin B(Amfamide) of the formula I, which consists in the fact that the synthesis is carried out by condensation of amphotericin B with ethylenediamine in the form of a free base in the presence of a condensing agent and a salt of an organic base and a mineral acid and the purification of the resulting crude amfamide is carried out by the method for reverse phase chromatography.
EFFECT: a new method for obtaining amfamide with a high yield is developed, which can find its application in medicine as an agent with antifungal properties.
5 cl, 2 dwg, 3 ex
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