IMMUNOCYTOKIN INCLUDING A HETERODIMERIC PROTEIN COMPLEX BASED ON ОСНОВЕ IL-15/IL-15Rα AND ITS APPLICATION Russian patent published in 2021 - IPC A61K38/19 A61K39/395 A61P35/00 

FIELD: cancer treatment.

SUBSTANCE: inventions group relates to the therapy of cancer and autoimmune diseases. An immunocytokine to stimulate the activation and/or proliferation of IL-15Rbeta/gamma-positive cells includes a heterodimeric protein complex based on IL-15 and IL-15Rα containing IL-15Rα and IL-15 that are linked to the constant domain of the antibody light chain, or constant domains of the heavy chain of an antibody comprising the first (CH1) constant domain of the heavy chain and an Fc fragment monomer containing the second (CH2) and third (CH3) constant domains of the heavy chain, where, if IL-15 or IL-15Rα is linked to an antibody light chain constant domain, another portion of the heterodimeric protein complex selected from IL-15Rα or IL-15 is linked to antibody heavy chain constant domains. Also disclosed is an isolated nucleic acid, an expression vector, a host cell for producing an immunocytokine, a pharmaceutical composition, a method for treating an oncological disease, and a method for activating the biological activity of a T-cell population or NK-cell population in a subject.

EFFECT: invention provides increased activity in the treatment of cancer.

78 cl, 25 dwg, 4 tbl, 12 ex