METHOD FOR OPTIMIZING TREATMENT OF STROMAL TUMORS OF GASTROINTESTINAL TRACT Russian patent published in 2021 - IPC A61K31/506 A61P35/00 

FIELD: medicine.

SUBSTANCE: invention relates to medicine and is intended to optimize the treatment of stromal tumors of the gastrointestinal tract with imatinib. The method involves the introduction of a predetermined fixed amount of imatinib mesylate in a daily dose of 400 mg. Blood sampling is carried out after the first 30 days of treatment. The minimum level of imatinib in blood plasma is determined by high-performance liquid chromatography and tandem mass spectrometry. Identification of the values at which an adjustment of the dose of imatinib mesilate is necessary, repeated control determination of the drug concentration in the blood serum 30 days after the adjustment. If the level of imatinib is detected within 500-899 ng/ml, the daily dose is increased by 200 mg, if the level of imatinib is detected below 500 ng/ ml, the daily dose is increased by 400 mg, if the level of imatinib is detected above 1500 ng/ml, the daily dose is reduced by 200 mg, and if the level of imatinib is detected within 900-1500 ng/ml, treatment is continued at the previous daily dose.

EFFECT: invention makes it possible to change the daily dose of imatinib in a timely manner based on data on the concentration of the drug in the plasma of patients and to increase the effectiveness of treatment and the quality of life due to an individual approach to the treatment of this group of patients.

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