FIELD: biochemistry.
SUBSTANCE: invention relates to the field of biochemistry, in particular to a genetically modified mouse, a germ line genome of which contains the first constructed endogenous locus of a light chain of κ immunoglobulin, containing one or more segments of human Vλ gene, one or more segments of human Jλ gene, one mouse Cλ gene, and one or more regulatory sequences.
EFFECT: invention is effective for the production of an antibody.
16 cl, 24 dwg, 2 tbl, 7 ex
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