FIELD: biotechnology.
SUBSTANCE: invention relates to biotechnology, in particular, the invention provides a method for obtaining amplified methylome by elongating fragments and treating elongated fragments with methyltransferase and a source of methyl groups for the transformation of semi-methylated double-stranded DNA into fully methylated double-stranded DNA.
EFFECT: technical result is creation methods for DNA amplification to preserve methylation status.
61 cl, 7 dwg, 6 ex
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